BFAD DEPARTMENT OF HEALTH ADMINISTRATIVE ORDER NO. 4A-00 DEPARTMENT OF AGRICULTURE A ADMINISTRATIVE ORDER NO. 1-00, January 11, 2000
BANNING AND WITHDRAWAL OF OLAQUINDOX AND CARBADOX FROM THE MARKET[]
production to reduce Salmonella shedding in animals. Both drugs have
long withdrawal period of about 70 days. The parent compounds of both
drugs possess genotoxic potential. Absence of specific toxicity studies
on the metabolites and the slight increase in the incidence of adrenal
cortex adenomas in male mice have prompted the Joint Expert Committee on
Food Additives of the Food and Agriculture Organization of the World
Health Organization not to establish an acceptable daily intake for
these two active ingredients. Studies also indicate that possible
exposure of workers handling the product to the parent molecules may
pose a real risk of irritation, allergy, anaphylactic shock and other
cumulative effects.
The Subcommittee on Veterinary Drugs of the National Drug Committee
of the Department of Health therefore conclude that the potential
hazards in the use of these drugs outweigh the benefits derived from the
use of these products.
Now, therefore, we, the Secretary of Agriculture and the Secretary of Health, jointly and severally order the following:
1. Olaquindox and Carbadox shall no longer be allowed for use in
all food producing animals, including in aquaculture regardless of the
route of administration.2. Registration of Olaquindox and Carbadox for use in food
producing animals shall be immediately withdrawn and future application
for similar registration shall be disapproved.3. All existing stocks of both drugs shall be immediately withdrawn from all distribution outlets.
4. All concerned personnel are instructed to implement the ban and educate the public on the reason to such ban.
This Order shall take effect fifteen (15) days after publication in a newspaper of general circulation.
Adopted: 11 Jan. 2000
(SGD.) ALBERTO R. ROMUALDEZ, JR., M.D.
Secretary
Department of Health
(SGD.) EDGARDO J. ANGARA
Secretary
Department of Agriculture
[*] Also filed by the Department of Agriculture on 14 April 2000, see NAR Col. 11/2, p. 757